The Radnoti Langendorff Constant Pressure Non- re-circulating 130105EZ permits the researcher to create a constant Pressure non re-circulating Langendorff preparation for Mouse and Rat. The heart may be paced (see Radnoti Part number 140157 Pacing Electrode) or spontaneously beating. The system can be instrumented to measure left ventricular pressure(Scisense FT111B Ultra-Miniature Pressure Catheter recomended), apical force using the built-in pulley system in combination with a Isometric Force Transducer and coronary resistance. This version of the constant pressure Langendorff heart system uses a peristaltic pump to perfuse the heart. Since pressure is held constant, changes in coronary resistance are detected as changes in flow. By using multiple reservoirs or a syringe pump, different solutions or drug concentrations can be delivered to the heart and washed out. This type of system is often used for dose response studies in pharmacology. The heart chamber, components, and key perfusate lines are water-jacketed for superb temperature control.

The system uses a water-jacketed reservoir to maintain and gas the perfusion solution or buffer. A peristaltic pump draws from the reservoir and drives the solution up to a water-jacketed bubble trap via a water jacketed flex tube assembly, where bubbles are relieved from the flow, and then down to the aortic cannula into the heart chamber via a second water jacketed flex tube assembly. Radnoti water jacketed flex tube assemblies use a teflon inner tubing to prevent degassing during low flow experimentation. Effluent from the heart is directed to waste or collected for evaluation (For re-circulating of the buffer please see Radnoti 130106EZ and 130102EZ isolated heart systems). As the system is configured for constant pressure, changes in resistance from the heart will result in flow variations that can be monitored via an accessory flow meter(Transonics Flow Meter Recommended). For experimentation that requires the heart to autoregulate pressure, please see Radnoti constant flow systems 130103EZ and 130106EZ.

The Radnoti 130105EZ Constant Pressure Non re-circulating system comes complete with Lab Stand Assembly, all necessary tubing cut to size and pre-assembled and packaged by group for ease of installation, glassware and associated clamp hardware. Also included is the Radnoti 170051A Thermal Circulator Water Bath and a Peristaltic pump and pump head 170100-50, 170111. An accessory Tubing Connector Kit is also included for replacement connectors or minor variations to the system.

As with all Radnoti systems the, modular design allows for extreme flexibility and system reconfigurations.