M Series Wire Myographs

Request Quotation

Radnoti Wire Myograph System

Now our M4 4-channel system comes complete with digital microcope and monitor as standard features!

• Suitable for contractile force studies on small ring samples ranging from 60 um to over 1 mm diameter and segment lengths up to 3mm.
• Dissecting miscrope and monitor can be positioned over the low profile support stand to aid in visualization of the sample during mounting procedures.
• Chamber light illuminuates the 5ml chamber allowing better view of sample
• Ergonomic Wrist Holder allows ease and comfort of use
• Safety lock for the ultra sensitive force transducer, less worry about damaging the mechanics of the system while mounting the sample.
• Extremely precise independent isometric force transducers based on picofarad capacitance converted to DC voltage.
• Better calibration method on transducers, allow the myograph chamber to be calibrated while in the horizontal position
• Superb temperature control due to our independent M1600 Quick Start temperature controllers.
• Sturdy design: Sturdy steel base is coated to resist the corrosive salt solutions often associated with such experiments.
• Experimental Advantages: The transducer amplifiers with LCD display are mounted directly above each myograph chamber. This is of particular benefit during application of sample pre-load, equilibration and length tension curves.
• Easy to clean and replace buffer inlet, gas inlet and buffer outlet tubes. The tubes are fabricated of borosilicate glass to give the researcher a clear view of the fluid path during setup and experimentation.
• Compatible with all leading data acquisition and software manufactures.
• Available as four channel or single channel myograph system.

Overview of Radnoti Wire Myograph

Using precision fabricated micro vessel support brackets, the system accommodates lumen diameters down to 60μm and segment lengths up to 3mm. For samples with lumen diameters of 1mm or more, the standard Radnoti Tissue Organ Bath systems are recommended. To mount the vessel segment, two individual parallel wires are passed through the sample lumen and attached to the micro vessel support brackets. Each vessel support bracket incorporates a micro groove on the face to aid in maintaining the wire position when mounting. One bracket is connected to a precision 0 – 0.5gm capacitance type isometric force transducer (switchable to 0-5 gm and also available in 0-2 gm/0-20 gm configurations) that provides a true isometric measurement, i.e. less than 12.5μm deflection at 0.5gm force, which is critical when working with small vessel samples. The opposing support bracket is connected to a precision micrometer controlling the X axis movement, with Y and minor Z axis positioning controls conveniently positioned on the Myograph chamber, allowing for precise alignment of the micro vessel support brackets. The wires are then anchored via a locking screw on each of the brackets. The locking screws feature a small bushing that is incorporated under the screw head greatly improving capture of the support wire. A pre-load tension is then applied via adjustment of the X axis micrometer. Once mounted the sample is immersed into a 5ml working volume sample chamber that allows for filling, emptying and gassing of buffer solutions. A water-jacketed reservoir with a separate support stand is provided to permit convenient perfusion buffer exchanges. The elevation of the water jacketed reservoir provides a nominal pressure feed to the chambers simplifying fill cycles. Included is a water jacketed bath that can be used during the initial gross dissection that prepares the tissue segment for mounting. A vacuum flask is also provided with an appropriate manifold system to aid in empty cycles.