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Regulation of atrial contraction by PKA and PKC during development and regression of eccentric cardiac hypertrophy.

Date 2nd Jul '12
Author(s) Georges E. Haddad, Bernell R. Coleman, Aiqiu Zhao, and Krista N. Blackwell.
Journal Am J Physiol Heart Circ Physiol, Feb 2005; 288: H695 - H704.

Method Extract

under pentobarbital sodium sedation (50 mg/kg ip). The left atrial muscle was isolated and mounted vertically in a Radnoti tissue organ bath system, with one end attached to the organ bearer with field stimulation electrodes and the other end attached to an isometric force transducer (model FTO3, Grass, Quincy, MA). The transducer was mounted on a micromanipulator, so that fine ....steps to adjust the resting tension could elongate the muscle. All experiments were carried out at....

Keywords tissue bath, contraction, atrial muscle
Our Ref: 1854
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